abstract：:The substitution of amino acid (aa) 70 of arginine for glutamine and/or that of aa91 of leucine for methionine in the core protein in patients infected with hepatitis C virus (HCV) genotype 1b is associated with a poor response to pegylated interferon and ribavirin. Factors influencing these substitutions were sought ...

journal_title：Journal of medical virology

authors： Kobayashi M,Akuta N,Suzuki F,Hosaka T,Sezaki H,Kobayashi M,Suzuki Y,Arase Y,Ikeda K,Watahiki S,Mineta R,Iwasaki S,Miyakawa Y,Kumada H

更新日期：2010-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 07_BC strain has caused serious outbreaks among injection drug users in Taiwan since 2004. The objective of this study was to conduct a molecular epidemiological study of HCV genotypes in intravenous drug users in Taiwan. Blood samples and ...

journal_title：Journal of medical virology

authors： Lee YM,Lin HJ,Chen YJ,Lee CM,Wang SF,Chang KY,Chen TL,Liu HF,Chen YM

更新日期：2010-01-01 00:00:00

abstract：:Norovirus is a major etiologic agent in worldwide outbreaks of gastroenteritis associated with food as well as person-to-person transmission. The ubiquitous nature of Norovirus necessitates simple and rapid detection methods with high accuracy and sensitivity. To this end, several investigators have evaluated the usef...

journal_title：Journal of medical virology

authors： Yoda T,Suzuki Y,Yamazaki K,Sakon N,Kanki M,Kase T,Takahashi K,Inoue K

更新日期：2009-12-01 00:00:00

abstract：:The aim of the study was to evaluate the prevalence and risk factors of HPV in a gynecologic population attending outpatient clinics using two new molecular tests. The Amplicor HPV test and the Linear Array (LA) HPV Genotyping test were used for the detection of HPV DNA in 320 women. Multiple logistic regression was u...

journal_title：Journal of medical virology

authors： Papachristou E,Sypsa V,Paraskevis D,Gkekas A,Politi E,Nicolaidou E,Anifantis I,Psichogiou M,Tsitsika A,Hadjivassiliou M,Petrikkos G,Katsambas A,Creatsas G,Hatzakis A

更新日期：2009-12-01 00:00:00

abstract：:Human immunodeficiency virus 2 (HIV-2) infection is characterized by a slower disease progression and lower transmission rates. The molecular features that could be assigned as directly involved in this in vivo phenotype remain essentially unknown, and the importance of HIV-2 as a model to understand pathogenicity of ...

journal_title：Journal of medical virology

authors： Santos-Costa Q,Parreira R,Moniz-Pereira J,Azevedo-Pereira JM

更新日期：2009-11-01 00:00:00

abstract：:Although there is a low prevalence rate (around 1% of the population) of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in Chile, little is known about the diversity and molecular characteristics of the circulating viruses. In the present study, 40 HBV and 57 HCV samples from Santiago City, Chile, ...

journal_title：Journal of medical virology

authors： Di Lello FA,Piñeiro Y Leone FG,Muñoz G,Campos RH

更新日期：2009-11-01 00:00:00

abstract：:No data on antiviral response of HBV genotypes E-H are available so far although these HBV genotypes contribute significantly to the global HBV burden. Of 49 patients with HBV genotypes E-H, 23 received interferon (IFN)-alpha, 12 nucleos(t)ide analogues and 14 patients were untreated. HBV genotype was determined by di...

journal_title：Journal of medical virology

authors： Erhardt A,Göbel T,Ludwig A,Lau GK,Marcellin P,van Bömmel F,Heinzel-Pleines U,Adams O,Häussinger D

更新日期：2009-10-01 00:00:00

abstract：:Norovirus is one of the major causes of outbreaks and sporadic cases of acute gastroenteritis in young children worldwide. Obtaining local baseline information regarding this virus is important for developing and evaluating prevention strategies of norovirus transmission in children. The age, seasonal distribution and...

journal_title：Journal of medical virology

authors： Xu J,Yang Y,Sun J,Ding Y

更新日期：2009-10-01 00:00:00

abstract：:An anti-hepatitis A virus (HAV)-specific immunoglobulin M capture enzyme-linked immunosorbent assay (anti-HAV IgM ELISA) kit was re-designed for laboratory use and compared with a commercial anti-HAV IgM detection system using 58 serum samples collected from patients, vaccines, and healthy individuals. Because concord...

journal_title：Journal of medical virology

authors： Kiyohara T,Ouchi Y,Hasegawa Y,Sato T,Yoneyama T,Ishii K,Ito T,Wakita T

更新日期：2009-09-01 00:00:00

abstract：:Infection with human polyomaviruses BKV and JCV is asymptomatic, and lifelong and widespread, among the general population. However, in the setting of immunosuppression, secondary to medications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specime...

journal_title：Journal of medical virology

authors： Babakir-Mina M,Ciccozzi M,Alteri C,Polchi P,Picardi A,Greco F,Lucarelli G,Arcese W,Perno CF,Ciotti M

更新日期：2009-09-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a dynamic process during which molecular variants are selected continuously to adapt to changes. In addition to drug resistant mutations, sequential antiviral therapy may also lead to the selection of deleted mutants. To investigate this process, the following samples were collecte...

journal_title：Journal of medical virology

authors： Ji F,Zhou L,Ma S,Li F,Ding H,Zeng C

更新日期：2009-09-01 00:00:00

abstract：:Limited amount of information is available in Taiwan on the genetic or antigenic characteristics of influenza A virus prior to the establishment of a Taiwan surveillance network in 2000. Isolates of H1N1 and H3N2 viruses in Taiwan between 1980 and 2006 were studied, and part of the hemagglutinin gene was analyzed due ...

journal_title：Journal of medical virology

authors： Wang SF,Lee YM,Chan YJ,Liu HF,Yen YF,Liu WT,Huang JC,Chen YM

更新日期：2009-08-01 00:00:00

abstract：:Influenza epidemic is an important cause of severe illness in the elderly. Age-dependent morbidity of influenza in the elderly is associated with weakened immunity. The baseline age-related memory T cell activity in Chinese persons who are exposed to influenza virus through natural infection, are associated with the p...

journal_title：Journal of medical virology

authors： Jia N,Li C,Liu YX,Richardus JH,Feng D,Yang H,Dang RL,Ma YH,Xu XN,Cao WC

更新日期：2009-08-01 00:00:00

abstract：:Hepatitis C virus (HCV), exhibits considerable genetic diversity, but presents a relatively well conserved 5' noncoding region (5' NCR) among all genotypes. In this study, the structural features and translational efficiency of the HCV 5' NCR sequences were analyzed using the programs RNAfold, RNAshapes and RNApdist a...

journal_title：Journal of medical virology

authors： Araújo FM,Machado-Lima A,Durham AM,Teixeira R,Oliveira G

更新日期：2009-07-01 00:00:00

abstract：:The presence of HPV 16 E6*I/E6*II spliced transcripts, in cervical lesions of different grade, was analyzed to characterize the transcription pattern. The presence and amount of spliced transcripts were correlated with DNA viral markers such as E2/E6 ratio and physical state. The detection of HPV 16 E6*I/E6*II mRNAs w...

journal_title：Journal of medical virology

authors： Cricca M,Venturoli S,Leo E,Costa S,Musiani M,Zerbini M

更新日期：2009-07-01 00:00:00

abstract：:This retrospective study investigated and characterized the YMDD motif of the hepatitis B virus (HBV) reverse transcriptase (RT) gene, in sequential samples of 17 South African patients with chronic hepatitis B infection on lamivudine treatment. The profile of HBV genotypes as well as the genetic variability of pre-co...

journal_title：Journal of medical virology

authors： Selabe SG,Song E,Burnett RJ,Mphahlele MJ

更新日期：2009-06-01 00:00:00

abstract：:HIV diagnosis at the point-of-care or in resource-limited settings poses considerable challenges due to time and cost limitations. Currently, nucleic acid-based tests are the only reliable method for diagnosing recent infections during the window period post-infection and pre-seroconversion, but these tests are only s...

journal_title：Journal of medical virology

authors： Curtis KA,Rudolph DL,Owen SM

更新日期：2009-06-01 00:00:00

abstract：:Previous studies provided a direct experimental evidence for the contribution of HCV core protein in the development of insulin resistance (IR), but the clinical impact of HCV core region on IR is still not clear. The present study evaluated the impact of Amino acid (aa) substitutions of HCV-1b core region on IR in 12...

journal_title：Journal of medical virology

authors： Akuta N,Suzuki F,Hirakawa M,Kawamura Y,Yatsuji H,Sezaki H,Suzuki Y,Hosaka T,Kobayashi M,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kumada H

更新日期：2009-06-01 00:00:00

abstract：:Occult HBV infection is defined as the persistence of HBV DNA in individuals negative for HBV surface antigen (HBsAg), and many different mechanisms have been reported in different countries. However, in China, one of the endemic areas for HBV infection, no reports have been published on occult HBV infection. The pres...

journal_title：Journal of medical virology

authors： Fang Y,Teng X,Xu WZ,Li D,Zhao HW,Fu LJ,Zhang FM,Gu HX

更新日期：2009-05-01 00:00:00

abstract：:Regulatory T cells (T(reg)) provide a balance to immune T cell activation thereby protecting the body from pathogen-induced immunopathology. Several persistent viruses induce T(reg) that subvert protective immune mechanisms and promote viral persistence. Epstein-Barr virus (EBV) generally infects children subclinicall...

journal_title：Journal of medical virology

authors： Wingate PJ,McAulay KA,Anthony IC,Crawford DH

更新日期：2009-05-01 00:00:00

abstract：:Travel influences the spread of non-B subtypes of HIV in Europe. The aim of this study was to assess whether the spread of non-B subtypes occurred in Croatia, a country with a low level HIV infection. Phylogenetic analysis of the reverse transcriptase and protease genes was undertaken in 145 Croatian patients with the...

journal_title：Journal of medical virology

authors： Ramirez-Piedad MK,Lepej SZ,Yerly S,Begovac J

更新日期：2009-04-01 00:00:00

abstract：:The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...

journal_title：Journal of medical virology

authors： Cotte L,Trabaud MA,Tardy JC,Brochier C,Gilibert RP,Miailhes P,Trépo C,André P

更新日期：2009-04-01 00:00:00

abstract：:Human papillomavirus (HPV) RNA levels may be a more sensitive early indicator of predisposition to carcinogenesis than DNA levels. We evaluated whether levels of HPV-16 and HPV-18 DNA and messenger RNA (mRNA) in newly detected infections are associated with cervical lesion development. Female university students were ...

journal_title：Journal of medical virology

authors： Winer RL,Harris TG,Xi LF,Jansen KU,Hughes JP,Feng Q,Welebob C,Ho J,Lee SK,Carter JJ,Galloway DA,Kiviat NB,Koutsky LA

更新日期：2009-04-01 00:00:00

abstract：:A total of 82 samples from patients with cervical cancer (Group 1) and 50 samples from patients with other genital diseases (Group 2) were collected in Gansu, China. All 132 samples were tested for HPV DNA with a typing kit that can detect 21 types of HPV, and also tested for neutralizing antibodies against HPV-16, -1...

journal_title：Journal of medical virology

authors： Wu X,Zhang C,Feng S,Liu C,Li Y,Yang Y,Gao J,Li H,Meng S,Li L,Zhang Y,Hu X,Wu X,Lin L,Li X,Wang Y

更新日期：2009-04-01 00:00:00

abstract：:An attempt was made to identify factors influencing the cumulative probability of an increased alanine aminotransferase (ALT) level and hepatocarcinogenesis in hepatitis C patients with a normal ALT level initially. A total of 398 consecutive patients with a normal ALT level initially for 6 months or more and follow-u...

journal_title：Journal of medical virology

authors： Kumada T,Toyoda H,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Kanamori A,Atsumi H,Takagi M,Nakano S,Arakawa T,Fujimori M

更新日期：2009-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) core protein has been reported to alter the cell cycle in vitro, but the data remain inconclusive, and in vitro experiments do not represent precisely events that occur in vivo, which may involve hepatic inflammation or regeneration. A group of double-transgenic mice carrying tetracycline trans...

journal_title：Journal of medical virology

authors： Chang ML,Chen TH,Chang MY,Yeh CT

更新日期：2009-03-01 00:00:00

abstract：:KI is a novel polyomavirus identified in the respiratory secretions of children with acute respiratory symptoms. Whether this reflects a causal role of the virus in the human respiratory disease remains to be established. To investigate the presence of KIV in the respiratory tissue, we examined 20 fresh lung cancer sp...

journal_title：Journal of medical virology

authors： Babakir-Mina M,Ciccozzi M,Campitelli L,Aquaro S,Lo Coco A,Perno CF,Ciotti M

更新日期：2009-03-01 00:00:00

abstract：:Eastern equine encephalitis (EEE) is rare, but the most severe of the mosquito-borne encephalitides in the United States with a high case fatality rate of 30%. Here, we present a patient with EEE. EEE virus causes sporadic human disease in the Eastern parts of the United States, but the case we describe was a Scottish...

journal_title：Journal of medical virology

authors： Harvala H,Bremner J,Kealey S,Weller B,McLellan S,Lloyd G,Staples E,Faggian F,Solomon T

更新日期：2009-02-01 00:00:00

abstract：:Healthcare-associated infections with hepatitis C virus (HCV) hitherto have been observed mainly in hemodialysis settings as well as in hematology and oncology wards. In this communication, molecular and epidemiologic investigations to elucidate an HCV outbreak in an orthopedic ward are reported. One hundred and thirt...

journal_title：Journal of medical virology

authors： Ross RS,Viazov S,Khudyakov YE,Xia GL,Lin Y,Holzmann H,Sebesta C,Roggendorf M,Janata O

更新日期：2009-02-01 00:00:00

abstract：:Between 1999 and 2007 1,388 stool specimens from patients with acute flaccid paralysis or aseptic meningitis were submitted to the Austrian reference laboratory for poliomyelitis. Samples (201) yielded non-poliovirus enterovirus in culture. One hundred eighty-one viruses were available for typing and 78 isolates which...

journal_title：Journal of medical virology

authors： Ortner B,Huang CW,Schmid D,Mutz I,Wewalka G,Allerberger F,Yang JY,Huemer HP

更新日期：2009-02-01 00:00:00

abstract：:The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

journal_title：Journal of medical virology

authors： Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

更新日期：2009-01-01 00:00:00

abstract：:Therapy failure due to drug resistance development is a common phenomenon in HIV-infected patients. However, when the drug pressure leads to the earliest selection of drug-resistant HIV-1 populations is still unclear. In this study, the extent to which selection of the HIV-1 reverse transcriptase M184I/V mutations occ...

journal_title：Journal of medical virology

authors： Bergroth T,Ekici H,Gisslén M,Loes SK,Goh LE,Freedman A,Lampe F,Johnson MA,Sönnerborg A

更新日期：2009-01-01 00:00:00

abstract：:Enteric adenoviruses are important etiological agents associated with sporadic infections and outbreaks of acute gastroenteritis in infants and children. Fecal samples were collected from 439 hospitalized patients in the years 2005-2007 from Pune, Aurangabad, and Nagpur cities of western India to identify the most pre...

journal_title：Journal of medical virology

authors： Verma H,Chitambar SD,Varanasi G

更新日期：2009-01-01 00:00:00

abstract：:Studies of hepatitis B virus (HBV) infection in non-human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV infectivity in serial stages of acu...

journal_title：Journal of medical virology

authors： Tabuchi A,Tanaka J,Katayama K,Mizui M,Matsukura H,Yugi H,Shimada T,Miyakawa Y,Yoshizawa H

更新日期：2008-12-01 00:00:00

abstract：:The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...

journal_title：Journal of medical virology

authors： Sabol I,Matovina M,Gasperov NM,Grce M

更新日期：2008-12-01 00:00:00

abstract：:Noroviruses are an important cause of acute gastroenteritis. Increasing data showed that the GII-4 strains are predominant worldwide and new GII-4 variants emerge every 1-2 years causing major epidemics. Surveillance of gastroenteritis in hospitalized children under 5 years of age in China is described. Among 1,110 sp...

journal_title：Journal of medical virology

authors： Jin M,Xie HP,Duan ZJ,Liu N,Zhang Q,Wu BS,Li HY,Cheng WX,Yang SH,Yu JM,Xu ZQ,Cui SX,Zhu L,Tan M,Jiang X,Fang ZY

更新日期：2008-11-01 00:00:00

abstract：:Group A rotaviruses are the main cause of acute gastroenteritis in children worldwide. The intermediate capsid protein VP6 encoded by segment 6 of the dsRNA genome is the major structural component of the virus and it is highly antigenic and immunogenic. VP6 is responsible for group and subgroup (SG) specificities, al...

journal_title：Journal of medical virology

authors： Tavares Tde M,de Brito WM,Fiaccadori FS,Parente JA,da Costa PS,Giugliano LG,Andreasi MS,Soares CM,Cardoso Dd

更新日期：2008-11-01 00:00:00

abstract：:Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...

journal_title：Journal of medical virology

authors： Nacheva EP,Ward KN,Brazma D,Virgili A,Howard J,Leong HN,Clark DA

更新日期：2008-11-01 00:00:00

abstract：:Transmission of rotavirus infection was studied in a birth cohort of children based in an urban slum in Vellore and their familial contacts. Contemporaneous samples from index patients and their familial contacts were collected for analysis in three different settings. Firstly, samples were collected from familial con...

journal_title：Journal of medical virology

authors： Banerjee I,Primrose Gladstone B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

更新日期：2008-10-01 00:00:00

abstract：:The occurrence of viral coinfections in childhood pneumonia has received little attention, probably because suitable detection methods have been lacking. Between November 2004 and October 2006, the presence of 14 respiratory viruses in children aged less than 3 years old with community-acquired pneumonia were investig...

journal_title：Journal of medical virology

authors： Cilla G,Oñate E,Perez-Yarza EG,Montes M,Vicente D,Perez-Trallero E

更新日期：2008-10-01 00:00:00